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Saturday, March 13, 2010

PSYCHOKINETIC DIAGNOSTICS, QUANTUM-BIOPHYSICAL SEMEIOTICS EVOLUTION.


Introduction.

Since November 2007, I’ve been illustrating in numerous articles the bases of Quantum Biophysical Semeiotics (1-10). Then some famous websites have been helping me in spreading these developments of such physical semeiotics, representing a new physical tool, which proved to be reliable in bedside diagnosis, therapeutic monitoring and clinical research. For instance, with the aid of quantum-biophysical semeiotics, it’s possible in a few seconds to bedside recognize every constitution, as well as related inherited real risk, that predisposes positive individuals to the relative disorders (11-13). Starting from May 2009, some Commentaries have been posted even in the International Atherosclerosis Society website www.athero.org (14, 15)

At this point, I cannot understand the real reason why the numerous Biophysical-Semeiotic Constitutions, as well as relative inherited real risk, conditio sine qua non, e.g., of diabetes and malignancy, both solid and liquid, bedside recognized quickly with a stethoscope since birth, although such knowledge is accepted and spread among physicians by the majority of famous peer-reviews (See Bibliography in my website www.semeioticabiofisica.it), are not illustrated sufficiently and emphasised by National Health Services. In addition, traditional Medicine cannot highlight a lot of biological events, as Lory's experiment (8), because it knows exclusively local realm in biological systems, which brought about the psychokinetic diagnostics, for the first time described in this article.

As a matter of facts, in all tissues - besides local realm exists also NON-LOCAL Realm, as my friend Paolo Manzelli and I have demonstrated earlier in a lot of articles (1-10). Recognizing also a 4 Dimension Space/Time Matrix, wherein there are 2 SD and 2 TD, which provides a simultaneous information, not ruled by the old, out-moded-view of the world, deterministic, classic physics, but by quantum physics evolution (entanglement and disentanglement) we are able to understand why the first phase of hormone action is simultaneous with very beginning of whatever stimulation (for instance, intense digital pressure upon a bone, e.g., radius, is simultaneous to pancreas size increasing as response to endogenous osteocalcin!) (16) The second phase of hormone action mechanism, different in nature, is brought about by the contact of osteocalcin with relative receptors on beta-cell outer membrane of Langherans's islets (10, 21, 22).

In conclusion, mankind needs urgently open-minded physicians, Editors, and Reviewers, who are unavoidable to Medicine Progresses, as I wrote earlier (7, 24-28).

No Local Realm beside Local Realm in Biological Systems.

On the website of Harvard University Press, at http://www.hup.harvard.edu/catalog/LIBMIN.html http://www.hup.harvard.edu/catalog/LIBMIN.html, one may read such as statement:

Most notably, Libet's experiments reveal a substantial delay--the "mind time" of the title--before any awareness affects how we view our mental activities. If all conscious awarenesses are preceded by unconscious processes, as Libet observes, we are forced to conclude that unconscious processes initiate our conscious experiences”.

I have sent the following critical comment to Contact_HUP@harvard.edu, without receiving answer, neither for courtesy or good manner!

Dear Sirs, in your wonderful website at the URL http://www.hup.harvard.edu/catalog/LIBMIN.html, I've just read "Most notably, Libet's experiments reveal a substantial delay - the "mind time" of the title - before any awareness affects how we view our mental activities. If any conscious awareness is preceded by unconscious processes, as Libet observes, we are forced to conclude that unconscious processes initiate our conscious experiences". Such as sentence is not right, from Quantum Biophysical Semeiotics view-point, www.semeioticabiofisica.it

In fact, first of all, with the aid of this clinical tool, since 30 years I've been demonstrating that it's possible, rapid, and easy to bedside assess in reliable way microcirculatory function and structure of every biological system, including brain (14-23).

Secondly, Benjamin Libet did not know Quantum Biophysical Semeiotics, I have founded in 2007, November! Energy-Information, according to my friend Paolo Manzelli, an outstanding chemist, is simultaneous and not transmitted spending time and wasting energy, as it happens throughout biological systems, identical from embryogenesis view-point, both in the same individual and from subject to subject (not necessarily twin, as in Lory’s Experiment), regardless the distance between them (1-13)

As regards the future of Medicine, I am allowed to state that it’s already begun, as far as Biology and Physical Semeiotics are concerned. In fact, biological events are more complex, i.e., difficult to understand, than generally admitted today. Fortunately, the presence of no local realm, besides local realm, in Biological Systems (1-21), highlights the patho-physiological mechanisms underlying a lot of above-mentioned events, until now unknown, or erroneously explained, like Benjamin Libet's experiments (8).

Interestingly, the fundamental knowledge, Quantum Biophysical Semeiotics is based on, indicates that in all biological systems, both in human and animal, besides local realm, there is no local realm, wherein space/time matrix is jet quadric-dimensional, but showing 2 S/D and 2 T/D (1-11).

As a consequence, this type of information is “simultaneous” in space and “synchronous” in time, as Lory's Experiment demonstrates (8). In a few words, information appears simultaneously in a human body many kilometres far away from information’s origin, starting when the examiner is “thinking” to give somebody the information to do something.

At this point, I cannot understand the real reason why the numerous predispositions to disorders (i.e., Quantum Biophysical-Semeiotic Constitutions) (11-15), like diabetes and malignancy, both solid and liquid, as well as relative inherited real risks, bedside recognized with a stethoscope already at birth in a few seconds’ time due to Quantum Biophysical Semeiotics, already accepted and spread among physicians by the majority of famous peer-reviews will be tomorrow suggested by National Health Services. In addition, traditional Medicine cannot highlight a lot of biological events, e.g. Lory's experiment (8), because it knows exclusively the Local Realm in biological systems. On the contrary, in all tissues - besides that - really exists also NON-LOCAL Realm, as my co-worker friend Paolo Manzelli and I have demonstrated recently in 6 articles (1-16). Recognizing also a 4 Dimemsion Space/Time Matrix, wherein there are 2 SD and 2 TD, which provides a simultaneous Information, not ruled by the old, out-moded deterministic, classic physics, but by quantum physics evolution (entanglement and disentanglement) we are able to understand why the first phase of hormone action is simultaneous with a very beginning of whatever stimulation. For instance, intense digital pressure upon radius or vertebra bone is simultaneous to pancreas size increasing as response to endogenous osteocalcin! The second phase, different in nature, is brought about by the contact of osteocalcin with relate receptors on beta-cell outer membrane in Langherans's islets (1-14).

As a consequence, regarding Benjamin Libet’s theory, illustrate especially in Mind Time: "The Temporal Factor in Consciousness", from the above remarks, in the light of Quantum Biophysical Semeiotics, we must conclude that a new interpretation is unavoidably necessary!

As a matter of fact, in individual of experiment, in the parietal cerebral cortex, related to foot digital movement, even if the examiner is exclusively “thinking” to give a signal for muscle movement, e.g., of right big toe the circulation at base line, the circulation at base line simultaneously shows microcirculatory activation type I, associated.

When examiner says to the subject to be ready moving right big toe contemporaneously to a conventional signal, AL + PL + DL duration increases immediately to 7 sec. (NN = 6 sec.), paralleling “readiness potentials”. Finally, soon thereafter signal begin, Plateau Line intensity raises at highest value, i.e., 9 sec. (11-13,17-20) (Fig. 1).

Fig. 1

In health, mean-intense digital pressure, applied upon parietal cerebral cortex skin projection area, brings about fluctuation of both upper and lowers ureteral reflex: vasomotion and respectivaly vasomotility. Transferred the parameter values of these fluctuations , even mentally, on cartesian axes system, doctor obtain diagram and tachygram, very rich of information.

Psychokinesis and Quantum-Biophysical Semeiotics.

The term psychokinesis (from the Greek “psyche” and “kinesis”, literally “movement from the mind”), also known as telekinesis, is a term referring to the direct influence of mind on a physical system that cannot be entirely accounted for by the mediation of any known physical energy. Examples of psychokinesis could include distorting or moving an object.

The study of phenomena said to be psychokinetic is notoriously an aspect of parapsychology.

Until now, there was no convincing scientific evidence that psychokinesis exists. However, in my opinion, based on strict interpretation of clinical experiments, quantum-biophysical in nature, I refer in following, the time has come to change our idea on it.

At the beginning of April, 2009, I started a research considering, as hypothesis 0, to falsify, the possibility that quantum entanglement could link distant patient to examining physician in a strict manner, so that trigger-points modifications in the first (patient) would bring about identical modification in the trigger points of second (doctor) and vice versa, according to the results of my earlier researches, initiated with Lory’s Experiment (1-11).

For instance, “intense” digital pressure upon patient’s precordium, i.e., heart skin projection area, even far away a lot of kilometres from examining physician, brings about “simultaneously” gastric aspecific reflex also in the later, exclusively when the first is involved by every cardiac disorders, e.g., by CAD (4-6, 15).

As a consequence, I felt myself authorized to consider such as fact, psychokinetic in nature, in the sense that doctor’s heart trigger points were “simultaneously” stimulated in the same way as patient’ ones, causing heart-gastric reflex also in doctor, but showing parameter values identical to those of distant subject: latency time, duration, intensity, and so on.

As a matter of facts, what happens under such as experimental condition is really complex, but completely enlightened by Quantum Biophysical Semeiotics (See later on). Starting from these theoretical bases – hypothesis 0, to confute – I have done a large number of experiments, in order to study what happens in “my” body, when I stimulate different trigger points by thinking, i.e., done by the mind, on a well defined subject, both healthy or ill, even a lot of kilometres far away from me, at the condition that I know him/her, at least per image, ignoring completely his (her) health condition. Obviously, I carried out such experiments also on known ill patients, but without knowing on the precise diagnosis.

Interestingly, I have subsequently applied the “mental” stimulation also on exact point of inner part of well-defined biological system, and it proved to be more precise, obviously. For instance, I suffer from outcome of lower myocardial infarct; exclusively when I stimulate “by thinking” the precise site of left ventricle involved by infarct scar, gastric aspecific reflex shows a pathological lateny time of 3 sec. Otherwise, latency time of heart-aspecific gastric reflex results normal, i.e., 8 sec., when I mentally apply digital pressure upon all diverse part of my heart. In fact, all other coronaries, both macro- and micro-coronary vessels, are normal, according to coronarographic examination, and, more precise, to quantum-biophysical-semeiotic results, which are the only to give information about coronary micro-circulatory bed (1-15).

Despite some human errors and late diagnoses, at least in initial stages of disorders, like those of Colleagues working in famous hospital, the interesting diagnoses, subsequently corroborated by means of direct examination, and then laboratory and image diagnostics, were: flu, pleuritis, pneumonitis, Oncological Terrain, breast cancer, arthrosis, a.s.o. In other words, I've examined at distance, utilising the psychokinetic diagnostics, 120 subjects, and I made their clinical diagnoses, corroborated subsequently by laboratory and image diagnostics, as the same individuals can confirm with pleasure.

Clinical Evidences demonstrate Psychokinetic Diagnostics Theory.

Firstly, we have to remember all microcirculatory events at the base of quantum-biophysical-semeiotic preconditioning (6,11-15,24-28).

In health, latency time of a reflex, e.g., heart-gastric aspecific reflex, paralleling tissue oxygenation level, at first evaluation is exact 8 sec., after 5 sec. interruption from the end of the first evaluation, raises to16 sec., doubling its basal value, due to Microcirculatory Functional Reserve physiological activation, Preconditioning is based on. Moreover, “intense” digital pressure, lasting one second, or more, upon hearth skin projection area (= Precordium), even kilometres away from examining doctor, does not bring about “simultaneously” gastric aspecific reflex, which occurs obviously after 8 sec. precisely, and lasts less than 4 sec., according to Lory’s Experiment (1-10).

At this point, if doctor apply really, for the first time, directly, “mean-intense” digital pressure on his (her) own heart skin projection, after precise 5 sec., namely performing heart preconditioning (6,26-28), the second latency time raises physiologically to16 sec., corroborating former heart distant stimulation, due to psychokinetic event: the psychocinetic diagnostic theory is thus corroborated.

To summarize in a few words, stimulating patient’s trigger-points only “by thinking”, i.e., “mentally”, despite the real distance between doctor and individual to be examined, brings about the possibility of physician’s preconditioning of every biological system, demonstrating thus the truth as well as the scientific significance of such diagnostics, made for the first time.

I term this original diagnosing method as Psychokinetic Diagnostics, which represents the paramount advancement of quantum-biophysical semeiotics: when physician is “thinking” about a well-known subject (analogously, to open radio!), i.e., having the subject on own mind, due to quantum entanglement, both peoples become part of a cosmic hologram, and can communicate each other, exchanging information (1-10).

Importantly, at this point, if Vibratory Energy (= ATP) is lowering in one or both communicating individuals, any exchange of information immediately stops. In addition, if examining doctor “imagines” the other subject as not lovely, even hateful, communication is not possible, in my opinion, demonstrating that Information Energy is LOVE!

As a consequence, in spite of the distance between them, when doctor is stimulating “by thinking some trigger points of an individual to be examined, the related visceral reaction, e.g., aspecific gastric reflex, appears also in doctor’s stomach, showing identical value parameters.

Interestingly to understand quantum nature of these events, if either doctor or subject to examine does not breath (= Apnoea test), lowering significantly tissue energy level, subsequently worsening mitochondrial respiratory chain activity, above-illustrated events stop quickly, after only one second, indicating the real nature of these events: reducing body Vibratory Energy (= ATP), according to P. Manzelli, also Information Energy lowers rapidly, so that quantum entanglement interrupt suddenly (= disentanglement), after only one second (1-10).

References.

1) Stagnaro Sergio e Paolo Manzelli. Semeiotica Biofisica: Realtà non-locale in Biologia. Dicembre 2007, www.ilpungolo.com, http://www.ilpungolo.com/leggi-tutto.asp?IDS=13&NWS=NWS5217

2) Stagnaro Sergio e Paolo Manzelli. Semeiotica Biofisica Quantistica. http://www.ilpungolo.com/leggi-tutto.asp?IDS=13&NWS=NWS5243

3) Stagnaro Sergio e Paolo Manzelli, 09-1-2008, Semeiotica Biofisica Quantistica: la manovra di attivazione surrenalica jatrogenetica http://www.fcenews.it/index.php?option=com_content&task=view&id=161&Itemid=63

4) Stagnaro Sergio. Pollio’s Sign in bedside Recognizing renal Cancer, since its initial Stage of Inherited, Oncological Real Risk. Sunday, March 22, 2009. http://sciphu.com/

5) Stagnaro Sergio. La Diagnosi Clinica nella Semeiotica Biofisica Quantistica. www.fce.it 02-05, 2008,

http://www.fcenews.it/index.php?option=com_content&task=view&id=1285&Itemid=47

6) Stagnaro Sergio. Semiotica Biofisica Quantistica: Diagnosi di Cuore sano in un Secondo in paziente distante 200 KM! www.fce.it, 07-05-2008

http://www.fcenews.it/index.php?option=com_content&task=view&id=1316&Itemid=47

7) Stagnaro Sergio. Role of NON-LOCAL Realm in Primary Prevention with Quantum Biophysical Semeiotics. www.nature.com, 01 Feb, 2008-05-17 http://www.nature.com/news/2008/080130/full/451511a.html

8) Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775

9) Stagnaro Sergio e Manzelli Paolo. Semeiotica Biofisica Quantistica: Livello di Energia libera tessutale e Realtà non locale nei Sistemi biologici. www.fce.it , 29 maggio 2008, http://www.fcenews.it/index.php?option=com_content&task=view&id=1421&Itemid=47

10) Stagnaro Sergio e Paolo Manzelli. Semeiotica Biofisica Endocrinologica: Meccanica Quantistica e Meccanismi d’Azione Ormonali. Dicembre 2007, www.fce.it, http://www.fcenews.it/index.php?option=com_content&task=view&id=816&Itemid=45

11) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/

12) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory.it/

13) Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/

14) Stagnaro Sergio. Stagnaro Sergio. Pre-Metabolic Syndrome and Metabolic Syndrome: Biophysical-Semeiotic Viewpoint. www.athero.org, 29 April, 2009. http://www.athero.org/commentaries/comm904.asp

15) Stagnaro Sergio. Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxigenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp

16) Stagnaro Sergio. Il test Semeiotico-Biofisico della Osteocalcina nella prevenzione primaria del diabete mellito. www.fce.it Febbraio 2008.

http://www.fcenews.it/index.php?option=com_content&task=view&id=909&Itemid=47 e alla URL http://www.clicmedicina.it/pagine-n-32/diabete-semeiotica.htm

17)Stagnaro S., Valutazione percusso-ascoltatoria della microcircolazione cerebrale globale e regionale. Atti, XII Congr. Naz. Soc. It. di Microangiologia e Microcircolazione. 13-15 Ottobre, Salerno , e Acta Medit. 145, 163, 1986

18)Stagnaro-Neri M., Stagnaro S., Deterministic chaotic biological system: the microcirculatoory bed. Theoretical and practical aspects. Gazz. Med. It. – Arch. Sc. Med. 153, 99, 1994

19) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Evaluation of Arterio-venous Anastomoses Dysfunction in early Arteriosclerosis. Acta Med. Medit. 5, 141, 1989.

20) Stagnaro-Neri M., Stagnaro S. Indagine clinica percusso-ascoltatoria delle unità microvascolotessutali della plica ungueale. Acta Med. Medit. 4, 91, 1988.

21) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm

22) Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1, and especially www.fce.it, http://www.fceonline.it/docs/stagnaro.pdf

24) Stagnaro Sergio. Bedside Biophysical-Semeiotic Osteocalcin Test in Diagnosing and Monitoring Diabetes. The Lancet, January 28, 2008.

http://www.thelancet.com/journals/lancet/article/PIIS0140673608601014/comments?action=view&totalComments=2; See http://www.fceonline.it/docs/stagnaro.pdf

25) Stagnaro Sergio. Comment to “Liz Wager: If comment is cheap why is peer review so expensive?”. www.BMJ.com, April 17th, 2009, http://blogs.bmj.com/bmj/2009/04/16/liz-wager-if-comment-is-cheap-why-is-peer-review-so-expensive/#comments

26) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.

27) Stagnaro Sergio. Middle Ages of today’s Medicine, Overlooking Quantum-Biophysical-Semeiotic Constitutions and Related Inherited Real Risk. http://sciphu.com November 4, 2008. http://sciphu.com/2008/11/meadle-ages-of-todays-medicine.html

28) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

* Sergio Stagnaro MD

Via Erasmo Piaggio 23/8

16039 Riva Trigoso (Genoa) Europe

Founder of Quantum Biophysical Semeiotics

Who's Who in the World (and America)

since 1996 to 2009

Ph 0039-0185-42315

Cell. 3338631439

www.semeioticabiofisica.it

dottsergio@semeioticabiofisica.it

Thursday, March 11, 2010

CAD Inherited Real Risk: Nosography and Therapy. The Concept of Angiobiopathy.



Introduction.

Mutations in parenchimal cell n-DNA and mit-DNA are the the conditio sine qua non of the most common human disorders, like diabetes and cancer, today’s epidaemics (1-17). In fact, all these diseases are based on a particular congenital, functional, mithocondrial cytopathy, transmitted through mother, I termed Congenital Acidosic Enzyme-Metabolic Histangiopathy, CAEMH (1, 13, 14). In addition, parenchymal gene mutations cause local microcirculatory remodelling, doctor can evaluate at the bedside in a reliable manner, gathering indirect information on relative parenchymal cell inherited modifications, since biological system functional modifications parallel gene mutation , according to Angiobiopathy theory (1,18, 19).

Nosography of CAD Inherited Real Risk.

In presence of intense CAEMH in a well-defined myokardial area, involved by gene mutations in both n-DNA and mit-DNA, can brings about CAD Real Risk, charcaterized by microcirculatory remodelling from biophysical-semeiotic viewpoint, especially intense under environmental risk factors (1, 6, 7, 16). Such as congenital microvascular remodelling, including also vasa vasorum of large coronary arteries, show since birth interesting structures, i.e., newborn-pathological, type I, subtype b), Endoarteriolar Blocking Devices, EBD, localized in small arteries, according to Hammersen, I discovered (See also www.semeioticabiofisica.it/microangiologia).

Interestingly, CAD Inherited Real Risk is associated to endothelial dysfunction (there are mitochondria also in endothels, although in small amount), doctor can bedside assess in easy and reliable way, at rest as well as under stress tests (1-10, 18, 19).

As a consequence of above, briefly referred remaks, physicians are able nowadays to demonstrate the presence of typical pathological EBDs in coronary microvessel, which play a central role in CAD Inherited Real Risk.

First of all, in health, due to the non local realm, present in all biological systems beside the local realm (20, 21), as I demonstrated earlier (2-25), “intense” digital pressure on cutaneous projection area of the hearth (precordium) (= activation of the local microcirculatory blood-flow, according to type I) do not provoke “simultaneously” aspecific gastric reflex, which occurs exactly after 16 sec. of latency time (1-5, 20, 21).

On the contrary, in case of CAD Real Risk, under the indentical experimental condition, referred above, doctor observes a gastric aspecific reflex “simoultaneous to intense digital pressure”, whose intensity parallels the seriousness of underlying disorder.

Fig. 1

Aspecific Gastric Reflex:in the stomach, both body and fundus are dileted,

whereas antel-pyloric regions contracts.

As a matter of facts, the hearth-aspecific reflex, reliable and easy to apply, brought about by “mean-intense” digital stimulation of cardiac trigger-points (precordium), appears after 8 sec. physiological latency time, but lasting 4 sec. (NN = less tha 4 sec.): this is an important parameter value, corresponding to Microcirculatory Functional Reserve (MFR) activity of related coronary microvessel, thus correlated with the function and anathomy of the microcirculatory bed, or more precisely speaking, microvascular tissular-unit.

In fact, hearth-aspecific gastric reflex, when pathologically lasting 4 sec. or more (NN less than 4 sec.), indicates local microcirculatory remodelling, and thus MFR impairment due to newborn-pathological, type I, subtype b), aspecific, EBD, which reduce tissue oxygenation, through lowering microcirculatory blood-flow.

Reliable and precise information is provided by hearth preconditioning in both its Inherited Real Risk and in very initial stage of CAD (6, 11), not to speak of clinical microcirculatory analysis, which needs a thorough knowledge of the original methods (www.semeioticabiofisica.it/microangiologia).

Discussion.

From the above remarks, Angiobiopathy theory results once again corroborated. As a matter of fact, according to this theory, which carries out Tischendorf’s Angiobiotopy, every inherited pathological condition of every parenchyma associates since birth with a subsequent modification of related microcirculatory bed, so that microcirculatory remodelling give reliable information on related parenchymal cells.

First of all, analogously to all other biological systems, appears the finctional alteration of the mitochondrial respiratory chain, i.e., CAEMH), after that, come congenital gene mutations (n-DNA and mit-DNA) in myocardial cells, which cause biological alterations, and thus local microcirculatory remodelling, associated with endothelial dysfunction.

Notoriously, negative environmental risk factors can worsen already present dangerous effects of such as gene inherited modifications (inherited real risk), but cannot independently bring about them directly.

Undoubtadly, metabolic syndrome (MS) is major target in Primary Prevention of today’s epidaemias: diabetes, dyslipidaemias, hypertension, a.s.o. However, we have firstly to remember beside "classic" form of MS also the "variant" one, I described earlier with a clinical method, conditio sine qua non of lithyasis (1-8) (See http://www.semeioticabiofisica.it and http://www.semeioticabiofisica.it/microangiologia.it). In addition, I described the Pre-Metabolic Syndrome (classic and "variant", of course) that follows biophysical-semeiotic constitutions, and comes for the MS, years or decades long: "Pre-Metabolic Stage" represents the LOCUS of primary prevention (1-6).

Finally, the above remarks account for the reason that only in some cases of MS, but not in ALL, there is diabetes, which is absent in a second subgroup of individuals with MS. Notoriously, patients with MS can be subdivided in two subgroups, as regards glucose metabolism impairment (25).

In fact, besides individuals showing IIR and/or high FPG and/or PPG levels, IGT, and finally diabetes, we observe patients with IIR, who will never suffer from diabetes. My 52 year-long clinical experience allows me to state that “biophysical-semeiotic dyslipidaemic AND diabetic” constitutions account for the reason of such as different outcome. Really, only patients with inherited pancreatic islet b-cell insufficiency, can be involved – in life-span – by insulin secretion failure, due to the exhaustion of hormone production (25).

As a consequence, cigarette smoking, diabetes, dyslipidaemias, hypertension, a.s.o., do not contribute to provoke CAD in ALL individuals, but exclusively in individuals among those involved by inherited CAD real risk (1, 11-13). Therefore, in all researches, aiming to recognize risk factors of human diseases, like cigarette smoking, inappropriate diet, hypertension, diabetes, a.s.o., especially individuals with the congenital real risk have to be enrolled. From the therapeutic viewpoint, in my long well-established clinical experience, diet ethimologically speaking, ConiugatedMelatonine, and NIR-LED application in pesonalized way, proved to be really efficacious against every inherited real risk form, including cancer real risk, due to their positive influence on mitochondrial respiratory function, which results normalized or even increased (26).

* Sergio Stagnaro MD

Via Erasmo Piaggio 23/8,

16039 Riva Trigoso (Genoa) Italy

Founder of Quantum Biophysical Semeiotics

Who's Who in the World (and America)

since 1996 to 2009

Ph 0039-0185-42315

Cell. 3338631439

www.semeioticabiofisica.it

dottsergio@semeioticabiofisica.it

References.

1.Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2.Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC.
Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298.
[MEDLINE].

3.Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica, con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante e tessutale Acta Med. Medit. 13, 99, 1997.

4.Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit. 13, 125, 1997.
5.Stagnaro Sergio. Endothelial cell function can ameliorate under safer drugs, such as Melatonin-Adenosine. BMC Cardiovascular disorders. http://www.biomedcentral.com/1471-2261/4/4/comments

6.Stagnaro-Neri M., Stagnaro S. Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of Ischaeemic Heart Disease even silent. Acta Medica Mediterranea 13, 109-116, 1997.

7.Stagnaro S. A clinical efficacious maneouvre, reliable in bed-side diagnosing coronary artery disease, even initial or silent, as well as "heart coronary risk". 3rd Virtual International Congress of Cardiology, FAC,2003,

http://www.fac.org.ar/tcvc/marcoesp/marcos.htm

8.Stagnaro Sergio.Biophysical Semeiotic Constitutions, Genomics, and Cardio-Vascular Diseases. BMC Cardiovascular Disorders, 2004, http://www.biomedcentral.com/1471-2261/4/20/comments#95454

9.Stagnaro Sergio Endothelial cell function can ameliorate under safer drugs, such as Melatonin-Adenosine. BMC Cardiovascular disorders. 2004

http://www.biomedcentral.com/1471-2261/4/4/comments

10.Stagnaro S. Pre-Metabolic Syndrome: Locus primary prevention. NYAS web site. 1999 http://www.memberconnections.com/olc/membersonly/NYAS/mboards.html

11.Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

12.Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1

13.Stagnaro Sergio. New bedside way in Reducing mortality in diabetic men and women. Ann. Int. Med.2007. http://www.annals.org/cgi/eletters/0000605-200708070-00167v1

14.Stagnaro S., Stagnaro-Neri M. Istangiopatia Congenita Acidosica Enzimo Metabolica. Gazz. Med. It.- Arch. Sci. Med. 144, 423, 1985.

15.Stagnaro S., Stagnaro-Neri M. Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz. Med. It. - Arch. Sci. Med. 149, 67 1990.

16.Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It.- Arch. Sc. Med. 152, 447 1993

17Stagnaro S., Stagnaro-Neri M., Oncological Terrain, conditio sine qua non of Oncogenesis, 2004: http://www.gutjnl.com/cgi/eletters?lookup=by_date&days=60

18.Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005, http://www.wjso.com/content/3/1/45/comments#205475

19.Sergio Stagnaro. Mitochondrial Genome of the Mastodon highlights Human Constitutions. PLOS Biology, (01 August 2007) http://biology.plosjournals.org/perlserv/?request=read-response&doi=10.1371/journal.pbio.0050207#r1725

20.Stagnaro Sergio. Biological System Functional Modification parallels Gene Mutation. www.Nature.com, March 13, 2008,

http://blogs.nature.com/nm/spoonful/2008/03/gout_gene.html

21.Stagnaro Sergio. Teoria Patogenetica Unificata, 2006, Ed. Travel Factory, Roma. 2006.

22. Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009..

23.Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775

24.Stagnaro Sergio e Paolo Manzelli, 09-1-2008, Semeiotica Biofisica Quantistica: la manovra di attivazione surrenalica jatrogenetica.

http://www.fcenews.it/index.php?option=com_content&task=view&id=161&Itemid=63

25. Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Sep;61(9):1143-4. Epub 2007 Feb 7. [MEDLINE]

26. Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/