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Wednesday, April 15, 2009

Oncological Terrain and Oncological Terrain-Dependent Inherited Real Risk in Malignancy Primary Prevention.

“Not to autumn I will yield, not to winter even”

Summary. 1
Introduction. 1
Congenital Acidosic Enzyme-Metabolic Histangiopathy- (CAEMH-). 2
Reticulo-Endothelial System Hyperfunction Syndrome. 2
Restano’s Manoeuvre Type A and Type B. 4
Oncological Terrain. 6
Simulated Sucking Test and Oncological Terrain. 9
Biophysical Semeiotic Evaluation of Epiphysial Secretion of Melatonin. 10
The Inherited “real risk” of cancer. 11
Conclusion. 11
References. 13


Malignancy efficacious primary prevention will be possible when doctor will bedside recognize, in a quantitative way and on very large scale, individuals at inherited real risk of tumour, allowing to direct rationally current diagnostic and therapeutic strategies. In the paper, biophysical-semeiotic diagnostic method, reliable in bed-side fast detecting and quantifying Oncological Terrain, i.e., oncological constitution, as well as Inherited Real Risk of malignancy, conditio sine qua non of cancer, solid as well as liquid, are fully described.


Before illustrating Clinical Microangiology of malignant tumours, both solid and liquid, it is necessary to describe in details the oncological terrain or oncological constitution, where is constantly present the Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAEMH), conditio sine qua non also of the oncological terrain, and, therefore, of malignancy, elsewhere exhaustively illustrated (1, 4, 5, 6) (See web site
CAEMH-, a congenital, functional, mythocondrial cytopathology, inherited almost from the mother, lasts all life long, although variable in intensity in relation to life-style, diet and employment of both bioactive products and histangioprotective drugs.
On the contrary, oncological terrain, originated on the basis of CAEMH-, can disappears under favorable condition, or increased by unfavourale enviromental situations, by improper diet, etymologically speaking, which acts in a negative manner on the CAEMH- severity as well as on the biological system controlling oncogenesis.
In other words, oncological terrain, wherein CAEMH- plays a major role, can be induced and fortunately reversed, almost completely, with the aid of correct diet, etymologically speaking, and by means of histangioprotective treatment (See later on).
Biophysical Semeiotics allows doctor to recognize and evaluate “quatitatively” the oncological constitution, i.e. oncological terrain, by the aid of a large number of methods, different in simplicity, refinement, practical application and amount of information. The usefulness of all these clinical methods, in general practitioner’s day-to-day work, is pointed out by the fact that absence of oncological terrain rules out the presence of malignancy, influencing remarkebly further diagnostic iter, large scale screening, and ultimately therapeutic monitoring.
In fact, age, sex, familiarity have now , i.e. from biophysical semeiotic point of view, a very little value in oncological prevention, because exclusively clinical recognition of oncological terrain requires urgently that patient undergoes instrumental and sophisticated semeiotics, promptly, in a rational manner, after ascertaining the microcirculatory activation type II, non-associated (1, 2) = pathological preconditioning in above-sited site  even in a small part of well defined biological system, where preconditioning results pathological, besides to other numerous biophysical semeiotic signs.
In every human, there are about 1013 cells: not all of these cells, but almost all, can grow and replicate to present as a clinical cancer in every time, due mutations occuring during cellular reproduction. However, cancer is a rare disease at the cellular level. As a matter of facts, up to 30% of all individuals in the developed countries will present clinically with one of a wide variety of cancer at some time of their life. Consequently, if the number of cell at risk is taken into account, given the relatively small cases of malignancies, solid and liquid, it is obvious that this disease only rarely escapes normal protective systems. Therefore, tumours can originate and grow exclusively when psycho-neuro-endocrine-immunological system is profoundly modified. As regards both primary prevention and clinical diagnosis of malignancy, in my opinion, essential is answering to the following question:
“What does carachterize oncological terrain from the clinical point of view?”.
In fact, in order to achieve efficacious prevention on very large scale it is unavoidable that all the modifications occurring in the biological controll system could be easily and promptly ascertained and properly evaluated with the aid of clinical method, i.e. by the use of a sthetoscope, and certainly without application of sophysticated semeiotics, that can not be applied on all individuals, and, moreover, only a few doctors can utilize them.
If the reply is affirmative, a second question immediately follows:
“The oncological terrain, which certanly can be induced, is also in some way reversible?”
It is urgent and necessary to know if the oncological terrain can be reversed, i.e. it can totally or greatly disappeare, with the aid of drugs or diet, etymologically speaking, which exert a favourable influence on modifications of the psicho-neuro-endocrine-immunological system.

Congenital Acidosic Enzyme-Metabolic Histangiopathy- (CAEMH-).
Reticulo-Endothelial System Hyperfunction Syndrome.

At first, we must both face and resolve essential problems concerning oncological terrain, discussing, once more, accurately the pathological mitochondrial condition, which represents its fundamental basis, when it is particularly severe: CAEM-. (3, 4, 5, 8-15) (See Congenital Acidosic Enzymo-Metabolic Histangiopaty in above-cited web site)
CAEM-, conditio sine qua non of oncological terrain and all other biophysical-semeiotic constitutions (See: Constitutions in web-site), represents really a severe alteration of mitochondrial oxidative phosphorilation processes, i.e. ATP synthesis, as well as nucleophyl substitution, variable in intensity from individual to individual, from tissue to tissue and from area to area of the same tissue.
From morphological view-point, it is well-known that CAEM- is characterized by prevalence of right cerebral hemisphere – right cerebral dominance – or more correctly said, of right Planum temporale, which is notoriously located between Heschl’s convolution (gyrus) and posterior part of Silvio’s fissure.
One can ascertain CAEM- as elsewhere described (See above). However, it is advisable an easiest manner, briefly illustrated in following: in healthy individual in supine position and psycho-physically relaxed, doctor applies its left hand, at first, on right parietal-temporal region of the subject, and then on the left one, when the individual to be examined presses forefinger-pulp and thumb-pulp together, obviously at first, of the left hand and, subsequently, of the right one; at the same time doctor evaluate somatosensorial evoked potentials (SEPs) (7-10) = in pratice, latency time of the cerebral-gastric aspecific reflex, as illustrated in Fig. above located.
In case of CAEM-, latency time (lt) of the reflex is 6 sec. when trigger-points of right hemisphere are stimulated, whereas lt results 7 sec. if left cerebral trigger-points are activated; in later situation, intensity of gastric aspecific reflex appears clearly smaller: 2 cm versus 1 cm. respectively. Of course, the degrees of reflex intensity are reversed in presence of dominance of left cerebral hemisphere.
At this point, in order to observe the interesting evolution from CAEM- to oncological terrain, one must remember, once a time, an usefull biophysical semeiotic syndrome, really helpful to general pracitioner in everiday activity : the Rethyculo-Endothelial System Hyperfunction Syndrome (RESHS), that is subdivided in “complete”, “intermediate” and “incomplete” type (6).
As far as clinical significance is concerned, CAEM- corresponds to increased ESR and proteins electrophoresis alterations, but surely is of both more sensitive, specific and, therefore, reliable. In fact, in case of a slight attack of flu, e.g., ( or, even, in advanced malignancy) it often turns out that both laboratory tests are in normal ranges, while RESHS “incomplete”, carachteristic of this viral disease, is always present since the first, asyntopmatic stage, when evaluated by aid of the Restano’s maneouvre = patient clinches fists and does not breath, i.e. boxer’s and simultaneously apnea test: sympathetic hypertonus (See later on): in healthy young person, psycho-physically relaxed, in supine position, digital pressure of “mean” intensity, applied on mean line of breast-bone, iliac crests and spleen projection area, provokes the gastric aspecific reflex after a latency time of 10 sec.: physiological RESHS (Fig.1).
In case of bacterial infection, contagious diseases of infancy, viral in origin, connective tissue disorders (Rheumatoid Arthritis, Lupus Erithematosus, a.s.o.), malignant tumours, a.s.o., lt decreases to 6 sec. with a latency time of reinforcing = augmentation of reflex intensity of 8  1 sec.: RESHS “complete”.
On the contrary, in commom viral diseases, as in flu, digital pressure, applied on cutaneous projection area of spleen does not brings about any gastric aspecific reflex, because white germ centres of splenic (red) pulp are not activated in these conditions: RESHS “incomplete”.
On the contrary, in Herpes Zoster as well as in common infectious diseases of infancy, caused by viral, interestingly doctor observes type “complete” RESHS
Finally, in bacterial disorders, provoked by Gram-negative, i.e. in common acute cystitis (E.coli) or in antritis brought about by H. pylori, RESHS turns out to be “intermediate” (Tab.1).

Fig. 1

Reticulo-Endothelial System Hyperfunction Syndrome: in the stomach, both fundus and body are clearly dilated, while antral-pyloric region contracts (= gastric aspecific reflex), when digital pressure of mean intensity is applied on middle line of breast-bone, iliac crests and, only in the “complete” type, also on cutaneous projection area of the spleen (See text and Tab 1).

RESHS: types and clinical significances.

Type “complete” Trigger points: breast-bone, iliac crests, skin projection area of spleen Bacterial diseases, viral contagious diseases of infancy, rheumatisms, malignancy
Type “intermediate” Splenic trigger point provokes a g.a. riflex of lower intensity Disorders caused by Gram-negative (Cistytis by Esch. coli; antritis by HP)
Type “incomplete” Spleen is not trigger-point Flu viruses

Tab. 1

Interestingly, RESHS allows doctor to monitoring in objective manner the course of wathever disorder in objective manner. As a matter of facts, the degree of both lt and lt of reflex reinforcing provides essential information about the course of the underlying illness.
From the practical view-point, it is of interest that exclusively during the changing of RESHES, from “incomplete” to “complete” type, doctor has to prescribe immediatly, without delay, antibiotic drugs.
A 46-year-long, well-established experience allows me to state that doctor can recognize easily, with the aid of Biophysical Semeiotics, individuals CAEMH-a-positive at oncological risk, quantifying it and estimating the probability of tumour in well-defined part of whatever biological system (11).

Restano’s Manoeuvre Type A and Type B.

In 85% of malignant tumours, both solid and liquid, in initial stage and in 100% when malignancy is sufficiently advanced, RESHS shows the “complete” type, chracterized by latency time (lt) of only 3 sec. and latency time of reinforcing of 5,5 ± 0,5 sec.
On the contrary, in common viral diseases of infancy and in bacterial disorders, connectivitis, a.s.o., lt is 6 sec. and latency time of reinforcing is 8,5±0,5 sec.; p <0,001. nn =" 10">10 sec.)
Healthies without familiarity for tumours CAEMH-a-neg. 8,5 ±0,5 sec. (10 sec.) 9,5±0,5 sec. (>10 sec.)
P.CAEMH-a-positive but at oncological risk and 15% P. with initial neoplasm 3 sec. (10 sec.) 7±1 sec. (>10 sec.)

Tab. 2

Restano’s manoeuvre

type A: lt 3 sec gastric aspecific reflex I £ 1 cm. tl II ³ 9 sec.
tipo B: tl 3 sec. gastric aspecific reflex I > 1 cm. tl II 6-8 sec.
Tab. 3

At this point, doctor must remember the essential role, Restano’s manoeuvre plays in moving from CAEMH-a syndrome to cancer growing. Restano’s manoeuvre represents, indeed, the activation of Reticulo-Endothelial-System (RES), at the present time termed Monocyte-Macrophage System. As indicates Tab. 3, there are two type of such as manoeuvre: type A and type B.
In order to perform correctly and to evaluate “quantitatively” the manoeuvre, subject, who undergoes examination, is invited not to breath for 10 sec. (apnea test), or alternatively doctor applies intense, occlusive digital pressure on a brachial artery for the same time (10 sec.), i.e. “variant” Restano’s manoeuvre, as well as to clinching fists: sympathetic hypertonus.
Before the individual keep again to normally breath, doctor applies digital pressure on middle line of breast-bone (or on iliac crests or cutaneous prjection area of the spleen) for evaluating RESHS = lt of gastric aspecific reflex,i.e. sundus and body of the stomach appear dilated, while antral-pyloric region contracts, and lt of reflex reinforcing (Tab. 1).
As described-above, Restano’s manoeuvre points out RES activation. As a matter of facts, e.g. during infectious disorder, it appears earlier type A, and then type B, and finally, “complete”, “incomplete” or “intermediate” type RESHS, in relation to the nature od underlying disese.
On the other hand, when therapy ameliorates disorder and patient improves, first of all RESHS disappears, and therafter also type B of the manoeuvre is not ascertained, while appears type A , which lasts as far as patient completely recovers.
The presence of Restano’s manoeuvre type B, i.e. the activation of Reticulo-Endothelial System, is due to the fact that marrow products mononuclear cells, which migrate to the thymus and lymphoid tissues, as well as myelopeptides, that stimulate antibodies synthesis, in order to increase biological defense. Consequently, there is marrow microcirculatory activation type I, associated = “light” digital pressure on breast-bone, e.g., provokes three ureteral reflexes, which permit doctor to evaluate vasomotility and vasomotion of marrow microcirculation, by the intensity of reflexes fluctuation. See web site .
Following experimental evidence corroborates my above-illustrated interpretation: in healthy, “intense” digital pressure on trigger-points for evaluating RESHS (middle line of breast-bone, iliac crests) after about 20 sec. increases the antibodies biophysical semeiotic syndrome (12) = light digital pressur, applied on MALT skin projection, i.e. breast-, liver-, spleen-, urinary bladder-, appendix-, middle clavicular line- a.s.o., cutaneous projection areas, provokes physiologically after 6 sec. gastric aspecific reflex of 2 cm. in intensity: chronic antibodies synthesis syndrome, that from the chronic type becomes clearly of acute type, where lt appears to be 3 sec. and intensity > 2 cm.
On the contrary, in individual with oncological terrain stimulation of antibodies synthesis appears to be whether absent or not statistically significant (lt of MALT-gastric aspecific reflex: 5-6 sec.). Moreover, in healthy, digital pressure on middle line of breast-bone, after a lt of about 20 sec., increases the diameters of BALT cutaneous projection area (­ 3 cm.), while in oncological terrain they increase only £ 1 cm. = auscultatory percussion of both posterior and anterior thoracic wall, allows doctor to ascertained , along middle scapular and, respectively, clavicular line, three round hypophonetic area – BALT - of a diameter oscillating in a chaotic-deterministic manner, 6 times/min, from 0,5 cm. to 1,5 cm., with a period varying from 9 sec. to 12 sec.- mean value 10,5, a fractal number, as do all biological systems.
Interestingly, in healthy individual digital pressure of mean intensity, applied on breast-bone provokes, after about 20 sec., intense increasing ( 2 cm.) of BALT cutaneous projection areas, with augmentation of antibodies synthesis (12) = lt of MALT-gastric aspecific reflex lowers from 3 sec. and reflex intensity clearly increases to  2 cm., while in presence of oncological terrain the encreases is £ 1 cm.).
To demonstrate both internal and external coherence of biophysical theory it is whortwhile that simultaneously, during Restano’s manoeuvre, all sites of antibodies synthesis (MALT) show biophysical semeiotic features of active hyperemia, more precisely speaking, the microcirculatory activation type I, associated (See earlier), of course of different intensity in relation to causal agent, indicating the acute phase of antibodies production.
Notably, the following clinical evidence corroborates this interpretation: in healthy, subcutaneous injection of desensitizing vaccine, according to Besredka, or, eg., anti-flu vaccine, induces first the type A, and later type B manoeuvre and finally RESHS.
While in Restano’s manoeuvre type A is always contemporaneously present Selye’s syndrome, variable in intensity, beside type B doctor observe characteristic modifications of psycho-neuro-endocrine-immunological system, as in malignancy, liquid or solid, as well as in patients, who successfully underwent to surgery. I have termed this pathological situation of biological systems for protecting against cancer as “oncological terrain”.
As regards the evaluation of neuro-stimulatotors, neuro-modulators, hormonal neuro-modulators, free-oxygen-radicals, and preconditioning see above cited web site.

Oncological Terrain.

Biophysical Semeiotics allows doctor to both recognize and “quantitatively” assess at the bed-side the biological terrain, on which cancer can originate and grow (Tab.4 and 5).

Increasing : G. H. I.G.F.s PRL free Radicals Hyperinsulinemia-insulinresistance
Reducing:: SST Oppioid Vit. A E Co. Q 10 Carnetine



BALT WITH CLOSED EYES LT> 5 SEC. I <> 5 SEC. I <> 5 SEC. I <> 5 SEC. I <> 20 SEC.
CAEMH- PRESENT (100%) G.aspecific REFL.> 2 CM.

Complete, exhaustive biophysical semeiotic evaluation of psycho-neuro-endocrine-immunological system as well as of products, indicated in Tab.5, needs obviously a years-long study and exprience at the bed-side. Due to lack of space, I invite the reader, who like to complete this topic, to see former articles (1-7) as well as Bibliography, in above-cited site.
However, I describe a method, easy to performe, reliable in detecting the presence of oncological terrain, as follows: in healthy, supine and psycho-physically relaxed, during rythmic palpation of breast (similuated sucking test, SST) the mammary gland-gastric aspecific reflex lasts 7 sec. exactly. On the contrary, in oncological terrain the duration augments to 8-9 sec. (p < nn =" 7" nn =" 3" nn ="="" nn =" 7" nn =" 10" nn =" 5" nn =" 9,12" nn =" <" nn =" 5" nn =" 5"> 10 sec., once again in correlation with the increasing of hormonal secretion, showing the possibility of evaluating simultaneously different disorders by means of Biophysical Semeiotics, since the numerous biological systems are connetted very closely from both structural and functional point of view.

At this point, oncological terrain is recognized and can be “quantitatively” evaluated, as follows:

4) assessment of endogenous opiates, the so-called “immunological orchestra directors”;

5) estimation of melatonin level, as described above.

As far as the evaluation of endogenous opiates system concerns, that can be activated also by melatonin and myelopeptides, a refined method is represented by assessment of cerebral-gastric aspecific reflex intensity, first, at basal line (NN ³ 2 < 3 cm.) and, then, after intense digital pressure on mandibular nerve for 25 sec., during Cerebral Evoked Potentials (8, 9, 10):
in healthy, intensity of cerebral gastric aspecific reflex is reduced to half., due to the restraining action of endogeous opiates as regards the neurotransmission;
By contrast, oncological terrain, carachterized by deficiency of b-endorphins as well as met-enkephalin, provokes a very small decreasing of cerebral-gastric aspecific reflex intensity under described condition.
As regards the rocognizing “real risk” of cancer, referred avove, doctor have to ascertain the impairement of latency time of gastric aspecific reflex, its duration, and above all the precious data of preconditioning.
In conclusion, one method, easy and rapid to perform, reliable in both diagnosing and “quantitatively” evaluating oncological terrain, in my opinion, is the following: closed eyes enhance melatonin epiphysial secretion, constantly reduced in oncological terrain, although whith different degree. Notoriously, melatonin stimulates diencephalohypophysial secretion of SST-RH as well as of endogenous opiates, particularly in arcuate nucleus. In addition, melatonin, somatostatin, and particularly endogenous opiates stimulate antibodies synthesis. Consequently, BALT cutaneous projection area, evaluated at rest and after 5 sec. eyes closure ( patient closes intensively his eyes) appears clearly modified and doubled in healthy for ³ 20 sec., whereas in oncological terrain, in relation to its intensity, changes are minimal (£ 1 cm.) for only £ 10 sec.
For further information, reader can see Bibliography in above-cited web site and in previous papers (1-5).


1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004.
2) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 1997; 13: 109-112.
3) Stagnaro S. A clinical efficacious maneouvre, reliable in bed-side diagnosing coronary artery disease, even initial or silent, as well as "heart coronary risk". 3rd Virtual International Congress of Cardiology, FAC, 2003, September-November.
4) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. 1983; Abstracts, pg 38, 28 Settembre-1 Ottobre, Bellagio1983
5) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. X Congr. Naz. Soc. It. di Microangiologia e Microcircolazione 1981. Atti, 61. 6-7 Novembre, Siena,1981.
6) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una Patologia Mitocondriale Ignorata. Gazz Med. It. – Arch. Sci. Med. 1985;144: 423-429 (Infotrieve)
7) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario. Min. Med. 1983;74: 479-480 (Medline)
8) Stagnaro S., Stagnaro-Neri M., Valutazione percusso-ascoltatoria del sistema degli oppioidi endogeni nei pazienti cefalalgici. Contributo alla definizione della costituzione emicranica. Epat. 1987; 33: 35-40.
9) Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 1993; 152: 447-451.
10) Stagnaro-Neri M. Stagnaro S., Diagnosi percusso-ascoltatoria e monitoraggio terapeutico della sindrome Magnesio-carenziale. Gazz. Med. It. – Arch. Sc. Med. 1988;147: 259-305.
11) Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 1992;151: 341-346.
12) Stagnaro Sergio. A paramount Bias in the Research. J. Clin. Invest.
13) Stagnaro Sergio. Bed-Side Prostate Cancer Detecting, even in early stages (“Real Risk” of Cancer): BMC Family Practice, 2005, 6:24 doi:10.1186/1471-2296-6-24 .
14) Stagnaro Sergio. There is another clinical, and overlooked tool, reliable in breast cancer prognosis evaluation (06 July 2005). BMC Cancer.
15) Stagnaro Sergio. Genes, Oncological Terrain, and Breast Cancer. (22 July 2005). World Journal of Surgical Oncology.
16) Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Travel Factory, Roma, 2004.
17) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient
Based Medicine. Travel Factory, Roma, 2004. 2004
18) Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005.

* Sergio Stagnaro MD
Via Erasmo Piaggio 23/8
16039 Riva Trigoso (Genoa) Europe
Founder of Quantum Biophysical Semeiotics
Who's Who in the World (and America)
since 1996 to 2009
Ph 0039-0185-42315
Cell. 3338631439

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